JMY Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

FLJ37870 antibody; Jmy antibody; JMY protein antibody; JMY_HUMAN antibody; junction mediating and regulatory protein antibody; Junction mediating and regulatory protein p53 cofactor antibody; Junction-mediating and -regulatory protein antibody; MGC163496 antibody; OTTHUMP00000161976 antibody; WAS protein homology region 2 domain containing 1-like 3 antibody; WHDC1L3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8N9B5

Immunogen

Recombinant Human Junction-mediating and -regulatory protein (708-848AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

JMY

Research Areas

Epigenetics and Nuclear Signaling; Cell biology