IWS1 Antibody

Size

100ul

Clone Number

Aliases

DKFZp761G0123 antibody; FLJ10006 antibody; FLJ14655 antibody; FLJ32319 antibody; Interacts with Spt6 antibody; iws1 antibody; IWS1 homolog antibody; IWS1-like protein antibody; IWS1_HUMAN antibody; IWS1L antibody; MGC126375 antibody; MGC126376 antibody; OTTHUMP00000162262 antibody; Protein IWS1 homolog antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96ST2

Immunogen

Recombinant Human Protein IWS1 homolog protein (570-819AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

IWS1

Research Areas

Epigenetics and Nuclear Signaling