ITGB3 Antibody

Size

100ul

Clone Number

Aliases

BDPLT16 antibody; BDPLT2 antibody; CD 61 antibody; CD61 antibody; CD61 antigen antibody; GP3A antibody; GPIIIa antibody; GT antibody; HPA 1 antibody; HPA 4 antibody; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody; Integrin beta chain beta 3 antibody; Integrin beta-3 antibody; ITB3_HUMAN antibody; ITG B3 antibody; ITGB 3 antibody; ITGB3 antibody; NAIT antibody; platelet fibrinogen receptor antibody; Platelet fibrinogen receptor beta subunit antibody; Platelet fibrinogen receptor, beta subunit antibody; Platelet glycoprotein IIIa antibody; Platelet glycoprotein IIIa precursor antibody; Platelet membrane glycoprotein IIIa antibody; PTP antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P05106

Immunogen

Recombinant Human Integrin beta-3 protein (609-788AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi\\\'s sarcoma lesions.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ITGB3

Research Areas

Cardiovascular; Immunology; Signal transduction