ITGAE  Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain| yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin| this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL)| and in addition to a role in adhesion| it may serve as an accessory molecule for IEL activation.

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human ITGAE (heavy chain| Cleaved-Ala179)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

129690

synonyms

ITGAE ;heavy chain; Cleaved-Ala179; Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD antigen CD103; Integrin alpha-E light chain; Integrin alpha-E heavy chain;