ITGA6 Antibody

Size

100ug

Clone Number

Aliases

Alpha6p antibody; CD49 antigen-like family member F antibody; CD49f antibody; Integrin alpha6B antibody; Integrin, alpha 6 antibody; ITA6_HUMAN antibody; ITGA6 antibody; ITGA6B antibody; Processed integrin alpha-6 antibody; VLA 6 antibody; VLA-6 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P23229

Immunogen

Recombinant Human Integrin alpha-6 protein (625-866AA)

Raised in

Rabbit

Species Reactivity

Human, Rat, Mouse

Tested Applications

ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:200-1:500

Background

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ITGA6

Research Areas

Developmental biology; Signal transduction; Stem cells