IRF9 Antibody

Size

100ug

Clone Number

Aliases

IFN alpha responsive transcription factor subunit antibody; IFN-alpha-responsive transcription factor subunit antibody; Interferon regulatory factor 9 antibody; interferon stimulated transcription factor 3 antibody; Interferon-stimulated gene factor 3 gamma antibody; interferon-stimulated transcription factor 3, gamma 48kDa antibody; IRF 9 antibody; IRF-9 antibody; Irf9 antibody; IRF9_HUMAN antibody; ISGF 3 gamma antibody; ISGF-3 gamma antibody; ISGF3 antibody; ISGF3 p48 subunit antibody; ISGF3G antibody; OTTHUMP00000164692 antibody; OTTHUMP00000164693 antibody; p48 antibody; Transcriptional regulator ISGF3 subunit gamma antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q00978

Immunogen

Recombinant Human Interferon regulatory factor 9 protein (44-180AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200

Background

Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

IRF9

Research Areas

Epigenetics and Nuclear Signaling; Immunology