Integrin  Alpha6 Monoclonal Antibody

Ab type

Primary antibody

Background

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.

Reactivity

Human,Mouse,Rat,Bovine,Dog,Pig

Clonality

Monoclonal

Host

Mouse

Isotype

IgG

Immunogen

Purified recombinant human Integrin α6 (N-terminus) protein fragments expressed in E.coli.

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

N/A

synonyms

ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f