INSIG1 Antibody

Size

100ug

Clone Number

Aliases

CL 6 antibody; CL6 antibody; INSI1_HUMAN antibody; INSIG 1 antibody; INSIG 1 membrane protein antibody; INSIG-1 antibody; insig1 antibody; INSIG1 membrane protein antibody; Insulin induced gene 1 antibody; Insulin induced gene 1 protein antibody; Insulin-induced gene 1 protein antibody; MGC1405 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O15503

Immunogen

Recombinant Human Insulin-induced gene 1 protein (1-87AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

INSIG1

Research Areas

Cancer; Cardiovascular; Metabolism; Signal transduction