ING4 Antibody

Size

100ug

Clone Number

Aliases

Brain my036 protein antibody; Candidate tumor suppressor p33 ING 1 homolog antibody; Candidate tumor suppressor p33 ING1 homolog antibody; D6Wsu147e antibody; D6Xrf92 antibody; ING 1 like protein antibody; ING 4 antibody; ING1 like protein antibody; ING4 antibody; ING4_HUMAN antibody; Inhibitor of growth family member 4 antibody; Inhibitor of growth family member 4 long isoform antibody; Inhibitor of growth protein 4 antibody; MGC12557 antibody; my036 antibody; p29 ING 4 antibody; p29 ING4 antibody; p29ING4 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UNL4

Immunogen

Recombinant Human Inhibitor of growth protein 4 protein (75-249AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor\'s (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance aopotosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

ING4

Research Areas

Epigenetics and Nuclear Signaling; Cancer