IMPACT Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

IMPACT antibody; Impact homolog (mouse) antibody; Impact homolog antibody; impact RWD domain protein antibody; IMPCT_HUMAN antibody; Imprinted and ancient gene protein homolog antibody; MGC33718 antibody; Protein IMPACT antibody; RWD domain containing 5 antibody; RWDD5 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9P2X3

Immunogen

Recombinant Human Protein IMPACT protein (41-320AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its action on GCN2, may also facilitate neuritogenesis.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

IMPACT

Research Areas

Epigenetics and Nuclear Signaling