IMPA1 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol| a precursor of phosphatidylinositol| and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1|4|5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1|3-diphosphate| myo-inositol-1|4-diphosphate| scyllo-inositol-phosphate| glucose-1-phosphate| glucose-6-phosphate| fructose-1-phosphate| beta-glycerophosphate| and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human IMPA1

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

30470

synonyms

IMPA1