IL36A Antibody

Size

100ul

Clone Number

Aliases

FIL1 antibody; FIL1 epsilon antibody; FIL1(EPSILON) antibody; FIL1E antibody; IL 1 epsilon antibody; IL 1F6 antibody; IL 1H1 antibody; IL-1 epsilon antibody; IL-1F6 antibody; IL1E antibody; IL1F6 antibody; IL1F6_HUMAN antibody; IL1RP2 antibody; IL36 alpha antibody; IL36A antibody; Interleukin 1 epsilon antibody; Interleukin 1 family member 6 (epsilon) antibody; Interleukin 1 family member 6 antibody; Interleukin 36 alpha antibody; Interleukin-1 epsilon antibody; Interleukin-1 family member 6 antibody; MGC129552 antibody; MGC129553 antibody; MGC151479 antibody; MGC151481 antibody; OTTMUSP00000012798 antibody; RP23-176J12.4 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UHA7

Immunogen

Recombinant Human Interleukin-36 alpha protein (1-158AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

IL36A

Research Areas

Immunology