IKZF1 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

CLL associated antigen KW 6 antibody; DNA-binding protein Ikaros antibody; hIk 1 antibody; Hs.54452 antibody; IK1 antibody; Ikaros (zinc finger protein) antibody; IKAROS antibody; IKAROS family zinc finger 1 (Ikaros) antibody; Ikaros family zinc finger protein 1 antibody; Ikzf1 antibody; IKZF1_HUMAN antibody; LYF1 antibody; Lymphoid transcription factor LyF-1 antibody; PRO0758 antibody; Zinc finger protein subfamily 1A 1 (Ikaros) antibody; Zinc finger protein subfamily 1A 1 antibody; Zinc finger protein; subfamily 1A; member 1 antibody; ZNFN1A1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13422

Immunogen

Recombinant Human DNA-binding protein Ikaros protein (1-265AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

IKZF1

Research Areas

Epigenetics and Nuclear Signaling; Cancer