IFITM3 Antibody

Size

100ug

Clone Number

Aliases

1 8U antibody; Fragilis antibody; IFITM3 antibody; IFM3_HUMAN antibody; Interferon induced transmembrane protein 3 (1 8U) antibody; Interferon Induced Transmembrane Protein 3 antibody; Interferon inducible antibody; Interferon inducible protein 1 8U antibody; Interferon Inducible Protein 15 antibody; Interferon Inducible Protein Homolog antibody; Interferon-induced transmembrane protein 3 antibody; Interferon-inducible protein 1-8U antibody; IP15 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q01628

Immunogen

Recombinant Human Interferon-induced transmembrane protein 3 protein (1-57AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IP; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IP:1:200-1:2000

Background

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

IFITM3

Research Areas

Developmental biology; Stem cells