IFIH1 Antibody

Size

100ug

Clone Number

Aliases

CADM-140 autoantigen antibody; Clinically amyopathic dermatomyositis autoantigen 140 kDa antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide antibody; DEAD/H box polypeptide antibody; Helicard antibody; Helicase with 2 CARD domains antibody; Hlcd antibody; IDDM 19 antibody; IDDM19 antibody; IFIH 1 antibody; Ifih1 antibody; IFIH1_HUMAN antibody; Interferon induced helicase C domain containing protein 1 antibody; interferon induced with helicase C domain 1 antibody; Interferon induced with helicase C domain protein 1 antibody; Interferon-induced helicase C domain-containing protein 1 antibody; Interferon-induced with helicase C domain protein 1 antibody; MDA 5 antibody; MDA-5 antibody; Melanoma differentiation associated protein 5 antibody; Melanoma differentiation-associated gene 5 antibody; Melanoma differentiation-associated protein 5 antibody; MGC133047 antibody; Murabutide down regulated protein antibody; Murabutide down-regulated protein antibody; RH 116 antibody; RH116 antibody; RIG I like receptor 2 antibody; RLR 2 antibody; RNA helicase DEAD box protein 116 antibody; RNA helicase-DEAD box protein 116 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BYX4

Immunogen

Recombinant Human Interferon-induced helicase C domain-containing protein 1 protein (700-1025AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2\'-O-methylation at their 5\' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

IFIH1

Research Areas

Epigenetics and Nuclear Signaling; Immunology; Microbiology