IER3 Antibody

Size

100ug

Clone Number

Aliases

DIF2 antibody; Differentiation-dependent gene 2 protein antibody; GLY96 antibody; IER3 antibody; IEX1_HUMAN antibody; IEX1L antibody; Immediate early protein GLY96 antibody; Immediate early response 3 antibody; Immediate early response 3 protein antibody; Immediately early gene X 1 antibody; PACAP-responsive gene 1 protein antibody; PRG 1 antibody; PRG1 antibody; Protein DIF 2 antibody; Protein DIF-2 antibody; Protein PRG1 antibody; Radiation-inducible immediate-early gene IEX-1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P46695

Immunogen

Recombinant Human Radiation-inducible immediate-early gene IEX-1 protein (1-82AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

IER3

Research Areas

Cancer; Cell biology; Stem cells