HTRA1 Antibody

Size

100ul

Clone Number

Aliases

ARMD7 antibody; CARASIL antibody; High-temperature requirement A serine peptidase 1 antibody; HtrA antibody; HtrA serine peptidase 1 antibody; HTRA1 antibody; HTRA1_HUMAN antibody; IGFBP5 protease antibody; L56 antibody; ORF480 antibody; Protease serine 11 (IGF binding) antibody; protease serine 11 antibody; PRSS11 antibody; Serine protease 11 antibody; Serine protease HTRA1 antibody; Serine protease HTRA1 precursor antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q92743

Immunogen

Recombinant Human Serine protease HTRA1 protein (23-248AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200

Background

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

HTRA1

Research Areas

Signal transduction