HTR2B Antibody

Size

100ul

Clone Number

Aliases

5 HT 2B antibody; 5 HT 2B receptor antibody; 5 HT(2B) antibody; 5 HT2B antibody; 5 hydroxytryptamine (serotonin) receptor 2B antibody; 5 hydroxytryptamine (serotonin) receptor 2B G protein coupled antibody; 5 hydroxytryptamine 2B receptor antibody; 5 hydroxytryptamine receptor 2B antibody; 5-HT-2B antibody; 5-HT2B antibody; 5-hydroxytryptamine receptor 2B antibody; 5HT(2B) antibody; 5HT2B Receptor antibody; 5HT2B_HUMAN antibody; 5HT2F antibody; Htr 2b antibody; Htr2b antibody; NP75 protein antibody; SEROTONIN 5HT2B RECEPTOR antibody; Serotonin receptor 2B antibody; Stomach fundus serotonin receptor antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P41595

Immunogen

Recombinant Human 5-hydroxytryptamine receptor 2B protein (382-481AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

HTR2B

Research Areas

Neuroscience; Metabolism