HSD3B7 Antibody

Size

100ug

Clone Number

Aliases

HSD3B73 beta-hydroxysteroid dehydrogenase type 7 antibody; 3 beta-hydroxysteroid dehydrogenase type VII antibody; 3-beta-HSD VII antibody; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase antibody; C(27) 3-beta-HSD antibody; EC 1.1.1.- antibody; Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase antibody; EC 1.1.1.181 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9H2F3

Immunogen

Recombinant Human 3 beta-hydroxysteroid dehydrogenase type 7 protein (131-197AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200

Background

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

HSD3B7

Research Areas

Signal transduction