HP1 Alpha Polyclonal Antibody

Ab type

Primary antibody

Background

CBX5 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. Chromobox protein homolog 5 is enriched in the heterochromatin and associated with centromeres. Chromobox protein homolog 5 has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. Chromobox protein homolog 5 is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Reactivity

Human;Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human CBX5. AA range:41-90

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

22225

synonyms

CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha