HP1 Alpha Polyclonal Antibody

Ab type

Primary antibody

Background

CBX5 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. Chromobox protein homolog 5 is enriched in the heterochromatin and associated with centromeres. Chromobox protein homolog 5 has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. Chromobox protein homolog 5 is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human HP1 alpha. AA range:58-107

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

22225

synonyms

CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha