HP Antibody

Size

100ul

Clone Number

5A5

Aliases

Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain, Haptoglobin beta chain], HP

Immunogen Species

Homo sapiens (Human)

UniProt ID

P00738

Immunogen

A synthesized peptide derived from human Haptoglobin

Raised in

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:50-1:200

Background

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

Clonality

Monoclonal

Isotype

Rabbit IgG

Purification Method

Affinity-chromatography

Conjugate

Non-conjugated

Buffer

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

HP

Research Areas

Cardiovascular