HNRNPD Antibody

Size

100ul

Clone Number

Aliases

ARE binding protein AUFI type A antibody; AU-rich element RNA-binding protein 1 antibody; AUF antibody; AUF1 antibody; AUF1A antibody; Heterogeneous nuclear ribonucleoprotein D0 antibody; hnRNP D antibody; hnRNP D0 antibody; Hnrnpd antibody; hnRNPD0 antibody; HNRPD antibody; HNRPD_HUMAN antibody; P37 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q14103

Immunogen

Recombinant Human Heterogeneous nuclear ribonucleoprotein D0 protein (1-306AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:1000, IHC:1:20-1:200

Background

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3\\\'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5\\\'-UUAG-3\\\' sequence and also weaker to the single-stranded 5\\\'-TTAGGG-3\\\' telomeric DNA repeat. Binds RNA oligonucleotides with 5\\\'-UUAGGG-3\\\' repeats more tightly than the telomeric single-stranded DNA 5\\\'-TTAGGG-3\\\' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3\\\'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

HNRNPD

Research Areas

Epigenetics and Nuclear Signaling