HMG-1 (Acetyl Lys12) Polyclonal Antibody

Ab type

Primary antibody

Background

HMGB1 encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. High mobility group box 1 plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of HMGB1 have been identified. Alternative splicing results in multiple transcript variants that encode the same protein.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized acetyl-peptide derived from the N-terminal region of human HMG-1 around the acetylation site of K12.

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

24894

synonyms

HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1