HIF-1 alpha (Acetyl Lys532) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Contains two independent C-terminal transactivation domains| NTAD and CTAD| which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID).|Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes| including| erythropoietin| glucose transporters| glycolytic enzymes| vascular endothelial growth factor| and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization| tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human HIF-1α (Acetyl Lys532)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

90860

synonyms

HIF-1α ;Acetyl Lys532; Hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS domain-containing protein 8