HER2/ErbB2(Phospho-Tyr1196) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However| it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer| stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways| such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported| with the most common allele| Ile654/Ile655| shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers| including breast and ovarian tumors. Alternative splicing results in several additional transcript variants| some encoding d

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human HER2 and ErbB2 (Tyr1196)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

HER2/ErbB2 ;Tyr1196 ; Receptor tyrosine-protein kinase erbB-2; EC 2.7.10.1; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340