HDAC8(Phospho Ser39) Polyclonal Antibody

Ab type

Primary antibody

Background

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human HDAC8 around the phosphorylation site of Ser39. AA range:5-54

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

41758

synonyms

Histone deacetylase 8; HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8