HDAC6 Antibody

Size

100ul

Clone Number

Aliases

CPBHM antibody; FLJ16239 antibody; HD 6 antibody; HD6 antibody; HDAC 6 antibody; HDAC6 antibody; HDAC6_HUMAN antibody; Histone deacetylase 6 (HD6) antibody; Histone deacetylase 6 antibody; JM 21 antibody; JM21 antibody; KIAA0901 antibody; OTTHUMP00000032398 antibody; OTTHUMP00000197663 antibody; PPP1R90 antibody; Protein phosphatase 1 regulatory subunit 90 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UBN7

Immunogen

Recombinant Human Histone deacetylase 6 protein (160-470AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

HDAC6

Research Areas

Epigenetics and Nuclear Signaling; Stem cells