HDAC5(Phospho Ser498) Polyclonal Antibody

Ab type

Primary antibody

Background

Histones play a critical role in transcriptional regulation| cell cycle progression| and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins| resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human HDAC5 around the phosphorylation site of Ser498. AA range:464-513

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

121992

synonyms

Histone deacetylase 5; HDAC5; KIAA0600; Histone deacetylase 5; HD5; Antigen NY-CO-9