HDAC1(Phospho Ser421) Polyclonal Antibody

Ab type

Primary antibody

Background

Histone acetylation and deacetylation| catalyzed by multisubunit complexes| play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2| it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human HDAC1 around the phosphorylation site of Ser421. AA range:387-436

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

55103

synonyms

Histone deacetylase 1; HDAC1; RPD3L1; Histone deacetylase 1; HD1