HCFC1 Antibody

Size

100ug

Clone Number

Aliases

C1 factor antibody; CFF antibody; HCF 1 antibody; HCF antibody; HCF C-terminal chain 6 antibody; HCF-1 antibody; HCF1 antibody; Hcfc1 antibody; HCFC1_HUMAN antibody; HFC1 antibody; Host cell factor 1 antibody; Host cell factor antibody; Host cell factor C1 (VP16 accessory protein) antibody; Host cell factor C1 antibody; MGC70925 antibody; MRX3 antibody; VCAF antibody; VP16 accessory protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P51610

Immunogen

Recombinant Human Host cell factor 1 protein (201-428AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 \\\'Lys-4\\\' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

HCFC1

Research Areas

Epigenetics and Nuclear Signaling; Cell biology; Microbiology