HAT1 Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by HAT1 (histone acetyltransferase 1)is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for HAT1.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human HAT. AA range:331-380

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

49513

synonyms

HAT1; KAT1; Histone acetyltransferase type B catalytic subunit; Histone acetyltransferase 1