HACD3 Antibody

Size

100ug

Clone Number

Aliases

HACD3 antibody; BIND1 antibody; PTPLAD1 antibody; Very-long-chain antibody; 3R)-3-hydroxyacyl-CoA dehydratase 3 antibody; EC 4.2.1.134 antibody; 3-hydroxyacyl-CoA dehydratase 3 antibody; HACD3 antibody; Butyrate-induced protein 1 antibody; B-ind1 antibody; hB-ind1 antibody; Protein-tyrosine phosphatase-like A domain-containing protein 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9P035

Immunogen

Recombinant Human Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 protein (1-145AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

HACD3

Research Areas

Epigenetics and Nuclear Signaling; Signal transduction