H2AFZ (Ab-4) Antibody

Size

100ul

Clone Number

Aliases

H2A histone family member Z antibody; H2A.z antibody; H2A/z antibody; H2afz antibody; H2AZ antibody; H2AZ_HUMAN antibody; Histone H2A.Z antibody; MGC117173 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P0C0S5

Immunogen

Peptide sequence around site of Lys (4) derived from Human Histone H2A.Z

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF, ChIP; Recommended dilution: WB:1:50-1:500, IHC:1:20-1:200, IF:1:1-1:10

Background

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

H2AFZ

Research Areas

Epigenetics and Nuclear Signaling