GZMA Antibody

Size

100ul

Clone Number

Aliases

CTL tryptase antibody; CTLA3 antibody; Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody; Cytotoxic T lymphocyte associated serine esterase 3 antibody; Cytotoxic T lymphocyte proteinase 1 antibody; Cytotoxic T-lymphocyte proteinase 1 antibody; Fragmentin 1 antibody; Fragmentin-1 antibody; GRAA_HUMAN antibody; Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3 antibody; Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3, Hanukah factor serine protease) antibody; Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3) antibody; Granzyme A antibody; Granzyme A precursor antibody; Granzyme-1 antibody; GZMA antibody; H factor antibody; Hanukah factor serine protease antibody; Hanukkah factor antibody; HF antibody; HFSP antibody; TSP1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P12544

Immunogen

Recombinant Human Granzyme A protein (29-262AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after \\\'Lys-31\\\' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after \\\'Lys-189\\\', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GZMA

Research Areas

Cell biology; Immunology