GSC2 Polyclonal Antibody

Ab type

Primary antibody

Background

Goosecoidlike (GSCL), a homeodomain-containing gene, resides in the critical region for VCFS/DGS on 22q11. Velocardiofacial syndrome (VCFS) is a developmental disorder characterized by conotruncal heart defects, craniofacial anomalies, and learning disabilities. VCFS is phenotypically related to DiGeorge syndrome (DGS) and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology. GSC2 is expressed in a limited number of adult tissues, as well as in early human development.

Reactivity

Human;Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human GSC2. AA range:131-180

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

21545

synonyms

GSC2; GSCL; Homeobox protein goosecoid-2; GSC-2; Homeobox protein goosecoid-like; GSC-L