GRK6 Antibody

Size

100ul

Clone Number

Aliases

FLJ32135 antibody; G protein coupled receptor kinase 6 antibody; G protein coupled receptor kinase GRK6 antibody; G protein-coupled receptor kinase 6 antibody; G protein-coupled receptor kinase GRK6 antibody; Gprk6 antibody; Grk6 antibody; GRK6_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P43250

Immunogen

Recombinant Human G protein-coupled receptor kinase 6 protein (1-170AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GRK6

Research Areas

Cardiovascular; Signal transduction