GRK2(Phospho-Tyr86) Polyclonal Antibody

Ab type

Primary antibody

Background

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human GRK2 (Phospho-Tyr86)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

GRK2 ;Phospho-Tyr86; Beta-adrenergic receptor kinase 1; Beta-ARK-1; EC 2.7.11.15; G-protein coupled receptor kinase 2