GRHL3 Antibody

Size

100ug

Clone Number

Aliases

Drosophila antibody; Grainyhead like 3 antibody; Grainyhead like protein 3 homolog antibody; Grainyhead-like protein 3 homolog antibody; grhl3 antibody; GRHL3_HUMAN antibody; Sister of mammalian grainyhead antibody; Sister of mammalian grainyhead protein antibody; SOM antibody; TFCP2L4 antibody; Transcription factor CP2 like 4 antibody; Transcription factor CP2-like 4 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8TE85

Immunogen

Recombinant Human Grainyhead-like protein 3 homolog protein (31-182AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5\\\'-AACCGGTT-3\\\' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GRHL3

Research Areas

Epigenetics and Nuclear Signaling