GRB7 Antibody

Size

100ul

Clone Number

Aliases

B47 antibody; Epidermal growth factor receptor GRB 7 antibody; Epidermal growth factor receptor GRB-7 antibody; GRB7 adapter protein antibody; GRB7 antibody; GRB7_HUMAN antibody; Growth factor receptor bound protein 7 antibody; Growth factor receptor-bound protein 7 antibody; OTTHUMP00000164349 antibody; OTTHUMP00000164350 antibody; OTTHUMP00000164351 antibody; OTTHUMP00000164352 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q14451

Immunogen

Recombinant Human Growth factor receptor-bound protein 7 protein (233-532AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5\\\'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GRB7

Research Areas

Signal transduction