GRB2 Monoclonal Antibody

Size

Clone Number

Aliases

Abundant SRC homology; Adapter protein GRB2; ASH; Ash protein; EGFRBP GRB2; Epidermal growth factor receptor binding protein; Epidermal growth factor receptor binding protein GRB2; GRB 2; GRB2 adapter protein; Grb2; GRB2_HUMAN; Grb3 3;

Immunogen Species

Human

UniProt ID

P62993

Immunogen

Purified recombinant human GRB2 protein fragments expressed in E.coli.

Raised in

Mouse

Species Reactivity

Human,Rat,Mouse,Monkey

Tested Applications

ELISA,WB;Recommended dilution:WB:1:500-1:5000

Background

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

Clonality

Monoclonal

Isotype

IgG1

Purification Method

Affinity purified

Conjugate

Non-conjugated

Buffer

Ascites

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GRB2

Research Areas

Cancer;Signal transduction