GPT2 Polyclonal Antibody

Ab type

Primary antibody

Background

GPT2 (glutamic--pyruvic transaminase 2) encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in GPT2 has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from GPT2 . at AA range: 190-270

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

57904

synonyms

GPT2; AAT2; ALT2; Alanine aminotransferase 2; ALT2; Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2