GPS1 Antibody

Size

100ul

Clone Number

Aliases

COP9 signalosome complex subunit 1 antibody; COP9 signalosome subunit 1 antibody; COPS1 antibody; CSN 1 antibody; CSN1_HUMAN antibody; FUS6/COP11; Arabidopsis; homolog of antibody; G protein pathway suppressor 1 antibody; GPS-1 antibody; Gps1 antibody; JAB1-containing signalosome subunit 1 antibody; Protein GPS1 antibody; Protein MFH antibody; SGN1 antibody; Signalosome subunit 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13098

Immunogen

Recombinant Human COP9 signalosome complex subunit 1 protein (222-491AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GPS1

Research Areas

Neuroscience; Cell biology; Signal transduction