GPR143 Antibody

Size

100ug

Clone Number

Aliases

ALBINISM OCULAR TYPE I antibody; G protein coupled receptor 143 antibody; G-protein coupled receptor 143 antibody; GP143_HUMAN antibody; GPR143 antibody; MOA1 antibody; NETTLESHIP FALLS TYPE OCULAR ALBINISM antibody; Ocular albinism type 1 protein antibody; Ocular albinism type 1 protein homolog antibody; Ocular albinism1 Nettleship Falls type antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P51810

Immunogen

Recombinant Human G-protein coupled receptor 143 protein (314-404AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GPR143

Research Areas

Neuroscience