GPC1 Antibody

Size

100ug

Clone Number

Aliases

FLJ38078 antibody; glypican antibody; Glypican proteoglycan 1 antibody; glypican1 antibody; GPC 1 antibody; Gpc1 antibody; GPC1_HUMAN antibody; Secreted glypican-1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P35052

Immunogen

Recombinant Human Glypican-1 protein (342-530AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GPC1

Research Areas

Neuroscience; Cancer; Signal transduction