Glypican-3 Polyclonal Antibody

Ab type

Primary antibody

Background

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. Glypican-3 encoded by GPC3 can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human GPC3. AA range:461-510

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

65563

synonyms

GPC3; OCI5; Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7