GLRB Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

GLRBGlycine receptor subunit beta antibody; Glycine receptor 58 kDa subunit antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P48167

Immunogen

Recombinant Human Glycine receptor subunit beta protein (355-472AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GLRB

Research Areas

Neuroscience; Signal transduction