GIT2 Polyclonal Antibody

Ab type

Primary antibody

Background

GIT2 encodes a member of the GIT protein family, ARF GTPase-activating protein GIT2, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. GIT2 has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. GIT2 undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human GIT2. AA range:361-410

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

84543

synonyms

GIT2; KIAA0148; ARF GTPase-activating protein GIT2; ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting prote