GGT1 Antibody

Size

100ug

Clone Number

Aliases

CD224 antibody; D22S672 antibody; D22S732 antibody; Gamma glutamyl transpeptidase antibody; Gamma glutamyltransferase 1 antibody; Gamma glutamyltranspeptidase 1 antibody; Gamma-glutamyltransferase 1 antibody; Gamma-glutamyltranspeptidase 1 light chain antibody; GGT 1 antibody; GGT antibody; GGT1 antibody; GGT1_HUMAN antibody; Glutamyl transpeptidase antibody; Glutathione hydrolase 1 antibody; GTG antibody; Leukotriene C4 hydrolase antibody; MGC96892 antibody; MGC96904 antibody; MGC96963 antibody; OTTHUMP00000028921 antibody; OTTHUMP00000197959 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P19440

Immunogen

Recombinant Human Glutathione hydrolase 1 proenzyme protein (13-225AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GGT1

Research Areas

Cancer; Metabolism; Signal transduction