GFER Antibody

Size

100ul

Clone Number

Aliases

ALR_HUMAN antibody; Augmenter of liver regeneration antibody; ERV1 antibody; ERV1 homolog antibody; Erv1 like growth factor antibody; FAD-linked sulfhydryl oxidase ALR antibody; GFER antibody; Growth factor augmenter of liver regeneration antibody; Growth factor erv1 like antibody; Hepatic regenerative stimulation substance antibody; Hepatopoietin antibody; Hepatopoietin protein antibody; hERV1 antibody; HPO antibody; HPO1 antibody; HPO2 antibody; HSS antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P55789

Immunogen

Recombinant Human FAD-linked sulfhydryl oxidase ALR protein (81-205AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

Background

Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GFER

Research Areas

Cell biology; Signal transduction